Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors

Abstract excerpt

Endochondral ossification generates most of the load-bearing bones, recapitulating it in human cells remains a challenge. Here, we report generation of SOX9+ sclerotomal progenitors (scl-progenitors), a mesenchymal precursor at the pre-condensation stage, from human pluripotent stem cells and development of osteochondral induction methods for these cells. Upon lineage-specific induction, SOX9+ scl-progenitors...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone health and treatments
• Share to Heterotopic Ossification and Related Conditions
• Share to Medical Imaging and Pathology Studies