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<i>Cryptococcus neoformans</i> rewires the conserved Wee1-CDK checkpoint through two divergent kinases required for replication-stress tolerance and virulence

2026-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Cell-cycle checkpoints couple cell division to environmental and intracellular stress. Here, we show that the human fungal pathogen Cryptococcus neoformans possesses two divergent Wee1-family kinases, CnSwe1 and CnSwe102, that retain conserved CDK-inhibitory activity but function differently from their counterparts in the canonical Saccharomyces cerevisiae morphogenesis checkpoint. The swe1 Δ...

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Identifiers and source

Literature Corpus work
0a684e56-84d5-54f3-898e-38fcdf47c79b
DOI
10.64898/2026.06.24.734400
Open publication

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