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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in <i>C. neoformans</i> during thermal stress

2024-06-11

Abstract excerpt

The fungus Cryptococcus neoformans is an opportunistic pathogen of people that reprograms its translatome to facilitate adaptation and virulence within the host. We studied the role of Hog1/p38 in reprogramming translation during thermal stress adaptation, and found that this pathway acts on translation via crosstalk with the Gcn2 pathway, a well-studied regulator of general translation control. Using a combinati...

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Literature Corpus work
fce2e0b0-d2a8-52e9-b97b-bebe6b79307c
DOI
10.1101/2024.06.11.598457
Open publication

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Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in <i>C. neoformans</i> during thermal stressDOI 10.1101/2024.06.11.598457
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