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Hog1/p38 regulates the integrated stress response (ISR) and global transcriptomic changes in <i>C. neoformans</i> during oxidative stress

2025-05-23

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen that is responsible for an estimated 112,000 deaths per year. We studied the role of the Hog1/p38 and Gcn2 signal transduction pathways during adaptation of C. neoformans to oxidative stress, a physiologically relevant stressor during infection. Using a combination of molecular assays and RNA-sequencing analysis in Hog1-, Gcn2-and double-deleted mutants,...

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Literature Corpus work
d9b9b7a3-273d-535c-8c7d-4cf08c73f464
DOI
10.1101/2025.05.19.654802
Open publication

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