Specialization of the HOG Pathway and Its Impact on Differentiation and Virulence of<i>Cryptococcus neoformans</i>

Abstract excerpt

The human pathogenic fungus Cryptococcus neoformans has diverged from a common ancestor into three biologically distinct varieties or sibling species over the past 10-40 million years. During evolution of these divergent forms, serotype A C. neoformans var. grubii has emerged as the most virulent and cosmopolitan pathogenic clade. Therefore, understanding how serotype A C. neoformans is distinguished from less...

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