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Article

A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.

Molecular biology of the cell - 1 Jul 2006

Bahn Yong-Sun, Kojima Kaihei, Cox Gary M, Heitman Joseph

Abstract excerpt

The stress-activated mitogen-activated protein kinase (MAPK) pathway is widely used by eukaryotic organisms as a central conduit via which cellular responses to the environment effect growth and differentiation. The basidiomycetous human fungal pathogen Cryptococcus neoformans uniquely uses the stress-activated Pbs2-Hog1 MAPK system to govern a plethora of cellular events, including stress responses, drug...

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Identifiers

PMID: 16672377
DOI: 10.1091/mbc.e06-02-0113
PMCID: PMC1483045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.PMID 16672377Read ↗

Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.Semantic proximity Read ↗

Hog1/p38 regulates the integrated stress response (ISR) and global transcriptomic changes in <i>C. neoformans</i> during oxidative stressSemantic proximity Read ↗

Specialization of the HOG Pathway and Its Impact on Differentiation and Virulence of<i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Remodeling of Global Transcription Patterns of <i>Cryptococcus neoformans</i> Genes Mediated by the Stress-Activated HOG Signaling PathwaysSemantic proximity Read ↗

Stress-Activated Protein Kinases in Human Fungal PathogensSemantic proximity Read ↗

A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiationSemantic proximity Read ↗

The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.Semantic proximity Read ↗

Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity of Cryptococcus neoformansSemantic proximity Read ↗

Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformansSemantic proximity Read ↗

A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.Semantic proximity Read ↗

A Flucytosine-Responsive Mbp1/Swi4-Like Protein, Mbs1, Plays Pleiotropic Roles in Antifungal Drug Resistance, Stress Response, and Virulence of Cryptococcus neoformansSemantic proximity Read ↗

Hog1 Regulates Stress Tolerance and Virulence in the Emerging Fungal Pathogen Candida aurisSemantic proximity Read ↗

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