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Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans

29 Nov 2021

Abstract excerpt

Genome copy number variation occurs during each mitotic and meiotic cycle and it is crucial for organisms to maintain their natural ploidy. Defects in ploidy transitions can lead to chromosome instability, which is a hallmark of cancer. Ploidy in the haploid human fungal pathogen Cryptococcus neoformans is exquisitely orchestrated and ranges from haploid to polyploid during sexual development and under various...

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PMID: 34843473
DOI: 10.1371/journal.pgen.1009935

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