Article
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2007
Liu Xiaoling, Holstege Henne, van der Gulden Hanneke, Treur-Mulder Marcelle, Zevenhoven John, Velds Arno, Kerkhoven Ron M, van Vliet Martin H, Wessels Lodewyk F A, Peterse Johannes L, Berns Anton, Jonkers Jos
Abstract excerpt
Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features also observed in sporadic basal-like breast cancers. They appear as high-grade tumors with high proliferation rates and pushing borders. On the molecular level, they are negative for hormone receptors and ERBB2, display frequent TP53 mutations, and express basal epithelial markers. To...
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