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Article

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers

18 Jan 2018

Abstract excerpt

Human breast cancer has been characterized by extensive transcriptional heterogeneity, with dominant patterns reflected in the intrinsic subtypes. Mouse models of breast cancer also have heterogeneous transcriptomes and we noted that specific histological subtypes were associated with particular subsets. We hypothesized that unique sets of genes define each tumor histological type across mouse models of breast...

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PMID: 29346386
DOI: 10.1371/journal.pgen.1007135

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