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A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast Cancer

2022-10-07

Abstract excerpt

Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new targeted therapies, but few TNBC mouse models exist. Here, we developed a novel TNBC murine model by mimicking two common TNBC mutations with high co-occurrence: amplification of the oncogene MYC and deletion of the tumor suppressor PTEN. This Myc;Ptenfl murine mo...

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Literature Corpus work
b1f8e6b4-614a-5d18-8e1c-6b38094e6b7f
DOI
10.1101/2022.10.07.511231
Open publication

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A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast CancerDOI 10.1101/2022.10.07.511231
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