Article

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

2017-08-25

Abstract excerpt

Despite intense efforts, the cure rates of childhood and adult solid tumors are not satisfactory. Resistance to intensive chemotherapy is common, and targets for molecular therapies are largely undefined. We have now found that the majority of childhood solid tumors, including rhabdoid tumors, neuroblastoma, medulloblastoma and Ewing sarcoma, express an active DNA transposase PGBD5 that can promote site-specific...

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Literature Corpus work: 49b31b0b-ffa3-5418-83d0-fcb00c017e34
DOI: 10.1101/181040

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