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The <i>piggyBac</i> derived transposase 5 (PGBD5) can interact with human <i>piggyBac</i> -like elements

2025-08-02

Abstract excerpt

PGBD5 is encoded by a gene domesticated at the chordate origin from a DNA transposon of the piggyBac family. During its evolution, PGBD5’s sequence has been under strong purifying selection among vertebrate genomes. This suggests PGBD5 functions in the development and physiology of chordates, as recently demonstrated in mouse and human brain development, where it was implicated in double strand DNA breaks on neur...

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Identifiers and source

Literature Corpus work
c5fae9e3-d2a2-5d23-9a6c-058f72590239
DOI
10.1101/2025.07.31.667870
Open publication

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The <i>piggyBac</i> derived transposase 5 (PGBD5) can interact with human <i>piggyBac</i> -like elementsDOI 10.1101/2025.07.31.667870
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