Article

Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment

2018-10-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Alzheimer’s disease (AD) is under considerable genetic influence. However, known susceptibility loci only explain a modest proportion of variance in disease outcomes. This small proportion could occur if the etiology of AD is heterogeneous. We previously found that an AD polygenic risk score (PRS) was significantly associated with mild cognitive impairment (MCI), an early st...

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Literature Corpus work: 0a2a5865-efd2-5528-b890-8f28231549c7
DOI: 10.1101/432443

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