Article
Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases.
Human molecular genetics - 28 May 2020
Howe Laurence J, Dudbridge Frank, Schmidt Amand F, Finan Chris, Denaxas Spiros, Asselbergs Folkert W, Hingorani Aroon D, Patel Riyaz S
Abstract excerpt
BACKGROUND: There is growing evidence that polygenic risk scores (PRSs) can identify individuals with elevated lifetime risk of coronary artery disease (CAD). Whether they can also be used to stratify the risk of subsequent events among those surviving a first CAD event remain uncertain, with possible biological differences between CAD onset and progression, and the potential for index event bias. METHODS: Using...
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