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Article

Genetic drivers of m6A methylation in human brain, lung, heart and muscle.

Nature genetics - 1 Aug 2021

Xiong Xushen, Hou Lei, Park Yongjin P, Molinie Benoit, Gregory Richard I, Kellis Manolis

Abstract excerpt

The most prevalent post-transcriptional mRNA modification, N6-methyladenosine (m6A), plays diverse RNA-regulatory roles, but its genetic control in human tissues remains uncharted. Here we report 129 transcriptome-wide m6A profiles, covering 91 individuals and 4 tissues (brain, lung, muscle and heart) from GTEx/eGTEx. We integrate these with interindividual genetic and expression variation, revealing 8,843...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34211177
DOI: 10.1038/s41588-021-00890-3
PMCID: PMC9112289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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