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Article

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities.

Free radical biology & medicine - 1 Oct 2013

Ronchi Juliana A, Figueira Tiago R, Ravagnani Felipe G, Oliveira Helena C F, Vercesi Anibal E, Castilho Roger F

Abstract excerpt

NADPH is the reducing agent for mitochondrial H2O2 detoxification systems. Nicotinamide nucleotide transhydrogenase (NNT), an integral protein located in the inner mitochondrial membrane, contributes to an elevated mitochondrial NADPH/NADP(+) ratio. This enzyme catalyzes the reduction of NADP(+) at the expense of NADH oxidation and H(+) reentry to the mitochondrial matrix. A spontaneous Nnt mutation in C57BL/6J...

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Identifiers

PMID: 23747984
DOI: 10.1016/j.freeradbiomed.2013.05.049

Genes

NNT

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