Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice.

doi:10.14814/phy2.70642

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Article

Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice.

Physiological reports - 1 Nov 2025

Ohse Margarete C, Rong Song, Schmidt Sonja, Balzer Michael S, Nikolin Christoph, von Vietinghoff Sibylle, Haller Hermann, Schmidt-Ott Kai M, Kiyan Yulia, Shushakova Nelli

Abstract excerpt

The genetic predisposition to high glucose-induced peritoneal membrane (PM) injury during peritoneal dialysis (PD) and its mechanisms are of substantial clinical interest. We compared PD-induced peritoneal injury between two closely related mouse substrains, C57BL/6J and C57BL/6N, which differ in the function of the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT). Nnt(+/+) C57BL/6N mice...

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Topics

Animals
Glucose
Mice, Inbred C57BL
Mice
NADP Transhydrogenase, AB-Specific
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Peritoneal Dialysis

Peritoneum

Male

Reactive Oxygen Species

NADP Transhydrogenases

Mice, Knockout

Fibroblasts

Macrophages

Mitochondrial Proteins

Source

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Identifiers

PMID: 41239551
DOI: 10.14814/phy2.70642
PMCID: PMC12618214

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