Article

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

2024-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Heart failure with preserved ejection fraction (HFpEF) is increasingly common but its pathogenesis is poorly understood. The ability to assess genetic and pharmacologic interventions is hampered by the lack of robust preclinical mouse models of HFpEF. We have developed a novel “2-hit” model, which combines obesity and insulin resistance with chronic pressure overload to recapitulate clinical fea...

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Literature Corpus work: 792dc9a7-c4a8-5370-8cbc-103715398eaa
DOI: 10.1101/2024.06.06.597821

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