Article
Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice.
Free radical biology & medicine - 1 Dec 2017
Navarro Claudia D C, Figueira Tiago R, Francisco Annelise, Dal'Bó Genoefa A, Ronchi Juliana A, Rovani Juliana C, Escanhoela Cecilia A F, Oliveira Helena C F, Castilho Roger F, Vercesi Anibal E
Abstract excerpt
The mechanisms by which a high fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunctions and redox imbalance. We hypothesized that a HFD would increase mitochondrial reliance on NAD(P)-transhydrogenase (NNT) as the source of NADPH for antioxidant systems that counteract NAFLD development. Therefore, we studied HFD-induced liver mitochondrial dysfunctions...
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