Article

Reducing Reactive Lipids Improves Cardiac Metabolic and Diastolic Function in Pulmonary Hypertension Models

2025-10-11

Abstract excerpt

<h4>Background</h4> Reactive oxygen species are increased across most pulmonary hypertension (PH) etiologies, resulting in increased reactive lipid dicarbonyls, which form protein adducts and impair mitochondrial function. We hypothesized that reducing reactive lipids would reduce right ventricular systolic pressure (RVSP) and improve cardiac function by eliminating protein-lipid damage feedback loops. <h4>Method...

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Literature Corpus work: 6f92aab0-1d5b-5e26-9bd5-b2c45fa3ad8b
DOI: 10.1101/2025.10.10.681763

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