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Article

Lack of mitochondrial NADP(H)-transhydrogenase expression in macrophages exacerbates atherosclerosis in hypercholesterolemic mice.

The Biochemical journal - 23 Dec 2019

Salerno Alessandro G, Rentz Thiago, Dorighello Gabriel G, Marques Ana Carolina, Lorza-Gil Estela, Wanschel Amarylis C B A, de Moraes Audrey, Vercesi Anibal E, Oliveira Helena C F

Abstract excerpt

The atherosclerosis prone LDL receptor knockout mice (Ldlr-/-, C57BL/6J background) carry a deletion of the NADP(H)-transhydrogenase gene (Nnt) encoding the mitochondrial enzyme that catalyzes NADPH synthesis. Here we hypothesize that both increased NADPH consumption (due to increased steroidogenesis) and decreased NADPH generation (due to Nnt deficiency) in Ldlr-/- mice contribute to establish a macrophage...

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PMID: 31803904
DOI: 10.1042/BCJ20190543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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