Article

Myofiber-specific FoxP1 knockout protects against pancreatic cancer-induced muscle wasting in male but not female mice

2024-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cachexia affects up to 80% of cancer patients and results in reduced quality of life and survival. We previously demonstrated that the transcriptional repressor Forkhead box P1 (FoxP1) is upregulated in skeletal muscle of cachectic mice and people with cancer, and when overexpressed in skeletal muscle is sufficient to induce pathological features characteristic of cachexia. However, the r...

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Literature Corpus work: 09f5b8a5-cc77-50c1-b8f7-1503c88e44c1
DOI: 10.1101/2024.09.17.613547

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