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Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia

1 May 2025

Abstract excerpt

Cancer cachexia is a debilitating metabolic disorder characterized by involuntary loss of body and muscle mass, leading to increased morbidity and mortality. We previously found that forkhead box P1 (FoxP1) upregulation in skeletal muscle causes muscle wasting and is required for muscle wasting in response to cancer. However, transcriptional networks targeted by FoxP1 in skeletal muscles undergoing cancer-induced...

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PMID: 40349340
DOI: 10.1016/j.celrep.2025.115689

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