Article

The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia

2025-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Cancer-driven cachexia is a deleterious syndrome which involves progressive loss of skeletal muscle mass with or without fat loss, fatigue, and weakness that cannot be reversed by nutritional intake. Recent studies have shown deregulation of endoplasmic reticulum (ER)-induced unfolded protein response (UPR) pathways in skeletal muscle in various catabolic conditions, including cancer growth. How...

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Literature Corpus work: 39405f07-8c20-5e01-b1cf-0581bf0f1d4b
DOI: 10.1101/2025.05.05.652304

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