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Article

Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans.

Molecular and cellular biology - 15 May 2017

Zygmunt Deborah A, Singhal Neha, Kim Mi-Lyang, Cramer Megan L, Crowe Kelly E, Xu Rui, Jia Ying, Adair Jessica, Martinez-Pena Y Valenzuela Isabel, Akaaboune Mohammed, White Peter, Janssen Paulus M, Martin Paul T

Abstract excerpt

Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate changes in skeletal myofibers and the cells that contact them, including satellite cells and motor neurons. Here we show that the protein O-fucosyltransferase 1 gene (Pofut1), which encodes a glycosyltransferase required for NotchR-mediated cell-cell signaling, has reduced expression in aging skeletal muscle. Moreover,...

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Identifiers

PMID: 28265002
DOI: 10.1128/MCB.00426-16
PMCID: PMC5477548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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