Article
DNA Damage Response and Metabolic Reprogramming in Health and Disease.
Trends in genetics : TIG - 1 Oct 2020
Chatzidoukaki Ourania, Goulielmaki Evi, Schumacher Björn, Garinis George A
Abstract excerpt
Nuclear DNA damage contributes to cellular malfunction and the premature onset of age-related diseases, including cancer. Until recently, the canonical DNA damage response (DDR) was thought to represent a collection of nuclear processes that detect, signal and repair damaged DNA. However, recent evidence suggests that beyond nuclear events, the DDR rewires an intricate network of metabolic circuits, fine-tunes...
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