Article

New purifications reveal yeast and human stress granule cores are discrete particles with complex transcriptomes and proteomes

2023-10-13

Abstract excerpt

<h4>SUMMARY</h4> Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ≈200 nm cores embedded in a diffuse shell. We have developed new purifications of budding yeast and mammalian (HEK293T cell) stress granule cores that do not rely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b52dd1ab-23d6-5b7b-8f03-37f6af321e0c
DOI: 10.1101/2023.10.12.562116

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New purifications reveal yeast and human stress granule cores are discrete particles with complex transcriptomes and proteomesDOI 10.1101/2023.10.12.562116Read

A little less aggregation a little more replication: Viral manipulation of stress granulesSemantic proximity Read

Super-resolved spatial organization of the nucleolar transcriptomeSemantic proximity Read

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stressSemantic proximity Read

Stress granules regulate stress-induced paraspeckle assemblySemantic proximity Read

Single-molecule imaging of mRNA localization and regulation during the integrated stress responseSemantic proximity Read

Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stressSemantic proximity Read

The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsatesSemantic proximity Read

Stress-specific differences in assembly and composition of stress granules and related foci.Semantic proximity Read

Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.Semantic proximity Read

Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocagesSemantic proximity Read

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAsSemantic proximity Read

Longitudinal and large-scale monitoring of transcriptome and RBP-RNA interactome in living cells by engineered protein nanocagesSemantic proximity Read