Article

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

2024-11-06

Abstract excerpt

The central melanocortin system links nutrition to energy expenditure, with melanocortin-4 receptor (MC4R) controlling appetite and food intake, and MC3R regulating timing of sexual maturation, rate of linear growth and lean mass accumulation. Melanocortin-2 receptor accessory protein-2 (MRAP2) is a single transmembrane protein that interacts with MC4R to potentiate it’s signalling, and human mutations in MRAP2 ca...

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Literature Corpus work: 09aaa8b6-c0e0-505a-90ba-5b7e0b69d6a6
DOI: 10.1101/2024.11.06.622243

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