Article

The single pass membrane protein MRAP2 regulates energy homeostasis by promoting primary cilia localization of the G protein-coupled receptor MC4R

2020-11-15

Abstract excerpt

<h4>ABSTRACT</h4> The G protein-coupled receptor MC4R (Melanocortin-4 Receptor) and its associated protein MRAP2 (Melanocortin Receptor-Associated Protein 2) are both essential for the regulation of food intake and body weight in humans and mice. MC4R localizes and functions at the neuronal primary cilium, a microtubule-based organelle that senses and relays extracellular signals. Here, we demonstrate that MRAP2...

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Literature Corpus work: f3f01725-6118-59df-9538-2840b0a570c6
DOI: 10.1101/2020.11.13.382325

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