Article

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways

2024-11-19

Abstract excerpt

The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed at hypothalamic neurons that has an important role in appetite suppression and food intake. Mutations in MC4R are the most common cause of monogenic obesity and can affect multiple signaling pathways including Gs-cAMP, Gq, ERK1/2, β-arrestin recruitment, internalization and cell surface expression. The melanocortin-2 receptor accessory pr...

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Literature Corpus work: dde3c654-44c0-5c92-954b-9264baf3d219
DOI: 10.1101/2024.11.19.622403

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