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Article

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2

2 Oct 2013

Abstract excerpt

Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains unknown. In this paper, we demonstrate that MRAP2a enables MC4R, a...

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PMID: 24085819
DOI: 10.1210/me.2013-1099

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Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2PMID 24085819Read ↗

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in ZebrafishSemantic proximity Read ↗

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Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiologySemantic proximity Read ↗

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MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variantsSemantic proximity Read ↗

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