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Article

Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.

Endocrine - 1 Jul 2018

Liang Jinye, Li Lei, Jin Xuanxuan, Xu Bingxin, Pi Linyu, Liu Shangyun, Zhu Wei, Zhang Cong, Luan Bing, Gong Lulu, Zhang Chao

Abstract excerpt

PURPOSE: Melanocortin-3 receptor (MC3R), melanocortin-4 receptor (MC4R), and a recently identified melanocortin-2 receptor accessory protein 2 (MRAP2), are highly expressed in hypothalamus and coordinately regulate energy homeostasis, but the single cellular transcriptome of melanocortin system remains unknown. Several infrequent MRAP2 variants are reported from severe obese human patients but the mechanisms on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29704154
DOI: 10.1007/s12020-018-1596-2

Genes

MRAP2

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Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.PMID 29704154Read ↗

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Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.Semantic proximity Read ↗

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.Semantic proximity Read ↗

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MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variantsSemantic proximity Read ↗

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