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Article

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R

23 Jan 2023

Abstract excerpt

The G protein-coupled receptor melanocortin-4 receptor (MC4R) and its associated protein melanocortin receptor-associated protein 2 (MRAP2) are essential for the regulation of food intake and body weight in humans. MC4R localizes and functions at the neuronal primary cilium, a microtubule-based organelle that senses and relays extracellular signals. Here, we demonstrate that MRAP2 is critical for the...

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PMID: 36692018
DOI: 10.1172/jci.insight.155900

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