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Article

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology

15 Jul 2020

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32679290
DOI: 10.1016/j.gene.2020.144949

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiologyPMID 32679290Read ↗

Pathophysiology of melanocortin receptors and their accessory proteins.Semantic proximity Read ↗

Identification of GLP1R and MCHR1 signaling as novel GPCR targets of MRAP2 proteinSemantic proximity Read ↗

Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors.Semantic proximity Read ↗

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.Semantic proximity Read ↗

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variantsSemantic proximity Read ↗

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signalingSemantic proximity Read ↗

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathwaysSemantic proximity Read ↗

MC4R in Central and Peripheral SystemsSemantic proximity Read ↗

Studies on the physiological functions of the melanocortin system.Semantic proximity Read ↗

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4RSemantic proximity Read ↗

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.Semantic proximity Read ↗

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.Semantic proximity Read ↗

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