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Article

Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin.

Neuroscience - 14 Jun 2016

Connolly C, Magnusson-Lind A, Lu G, Wagner P K, Southwell A L, Hayden M R, Björkqvist M, Leavitt B R

Abstract excerpt

Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymptomatic HD...

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Source

Identifiers

PMID: 27033979
DOI: 10.1016/j.neuroscience.2016.03.031

Genes

MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin.PMID 27033979Read ↗

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