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Article

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.

Human molecular genetics - 1 May 2013

Hsiao Han-Yun, Chen Yu-Chen, Chen Hui-Mei, Tu Pang-Hsien, Chern Yijuang

Abstract excerpt

Huntington's disease (HD) is an autosomal disease caused by a CAG repeat expansion in the huntingtin (HTT) gene. The resultant mutant HTT protein (mHTT) forms aggregates in various types of cells, including neurons and glial cells and preferentially affects brain function. We found that two HD mouse models (Hdh(150Q) and R6/2) were more susceptible than wild-type (WT) mice to lipopolysaccharide-evoked systemic...

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Source

Identifiers

PMID: 23372043
DOI: 10.1093/hmg/ddt036

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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