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Article

Mutant huntingtin confers cell-autonomous phenotypes on Huntington's disease iPSC-derived microglia.

Scientific reports - 22 Nov 2023

Stöberl Nina, Donaldson Jasmine, Binda Caroline S, McAllister Branduff, Hall-Roberts Hazel, Jones Lesley, Massey Thomas H, Allen Nicholas D

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by a dominantly inherited CAG repeat expansion in the huntingtin gene (HTT). Neuroinflammation and microglia have been implicated in HD pathology, however it has been unclear if mutant HTT (mHTT) expression has an adverse cell-autonomous effect on microglial function, or if they are only activated in response to the neurodegenerative brain...

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Identifiers

PMID: 37993517
DOI: 10.1038/s41598-023-46852-z
PMCID: PMC10665390

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