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Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

10 Dec 2019

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that often share neuromusculature, cognitive, behavioral, and personality deficits, with either a sporadic or genetic, familial etiology. In cases of familial ALS and FTD, G4C2 hexanucleotide repeat expansions (HRE) within chromosome 9 open reading frame 72 (C9orf72) are the predominant monogenic cause. ALS and...

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PMID: 31920478
DOI: 10.3389/fnins.2019.01298

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