Article

Selective sweep and phylogenetic models for the emergence and spread of pyrimethamine resistance mutations in <i>Plasmodium vivax</i>

2018-10-03

Abstract excerpt

Pyrimethamine resistance is a major concern for the control of human haemoprotozoa, especially Plasmodium species. Currently, there is little understanding of how pyrimethamine resistance developed in Plasmodium vivax in the natural field conditions. Here, we present first time the evidence of positive selection pressure on a dihydrofolate reductase locus and its consequences on the emergence and the spread of p...

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Literature Corpus work: 096e9896-9460-5bad-baf1-0375c639c39d
DOI: 10.1101/433128

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