Phylogenetic analysis suggests single and multiple origins of dihydrofolate reductase mutations in Plasmodium vivax.

Abstract excerpt

Pyrimethamine was first introduced for the treatment of malaria in Asia and Africa during the early 1980s, replacing chloroquine, and has become the first line of drugs in many countries. In recent years, development of pyrimethamine resistance in Plasmodium vivax has become a barrier to effective malaria control strategies. Here, we describe the use of meta-barcoded deep amplicon sequencing technology to assess...

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• Antimalarials
• Drug Resistance
• Malaria, Vivax
• Mutation
• Phylogeny