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Characteristics of<i>Plasmodium falciparum dhfr</i>Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987–2006

30 May 2008

Abstract excerpt

Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa. It is not known whether alleles that confer SP resistance also arose independently in Africa. We defined the coding region and microsatellite haplotypes of dhfr alleles in P. falciparum collected in Kilifi, Kenya, during 1987--2006, which spans the period...

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PMID: 18513156
DOI: 10.1086/588198

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