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Molecular Markers of In Vivo<i>Plasmodium vivax</i>Resistance to Amodiaquine Plus Sulfadoxine‐Pyrimethamine: Mutations in<i>pvdhfr</i>and<i>pvmdr1</i>

26 Jun 2008

Abstract excerpt

BACKGROUND: Molecular markers for sulfadoxine-pyrimethamine (SP) resistance in Plasmodium vivax have been reported. However, data on the molecular correlates involved in the development of resistance to 4-aminoquinolines and their association with the in vivo treatment response are scarce. METHODS: We assessed pvdhfr (F57L/I, S58R, T61M, S117T/N, and I173F/L) and pvmdr1 (Y976F and F1076L) mutations in 94 patients...

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PMID: 18582193
DOI: 10.1086/589882

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