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Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax : Evidence for Sequential Selection by Drug Pressure

22 Apr 2003

Abstract excerpt

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained from 55 P. vivax isolates (isolates Belem and Sal 1, which are established lines originating from Latin America, and isolates from patient samples from Thailand [n = 44], India [n = 5], Iran [n = 2], and Madagascar [n...

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PMID: 12709316
DOI: 10.1128/aac.47.5.1514-1521.2003

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