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Article

Determinants of human glucokinase activation and implications for small molecule allosteric control.

Biochimica et biophysica acta. General subjects - 1 Sept 2018

Li Quinn, Gakhar Lokesh, Ashley Spies M

Abstract excerpt

Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis. GK is known to undergo substantial conformational changes upon glucose binding. The monomeric enzyme possesses a highly exotic kinetic activity profile with an unusual sigmoidal dependence on glucose concentration. In this...

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Identifiers

PMID: 29885360
DOI: 10.1016/j.bbagen.2018.06.001
PMCID: PMC6051901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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