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Article

Dual allosteric activation mechanisms in monomeric human glucokinase.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Whittington A Carl, Larion Mioara, Bowler Joseph M, Ramsey Kristen M, Brüschweiler Rafael, Miller Brian G

Abstract excerpt

Cooperativity in human glucokinase (GCK), the body's primary glucose sensor and a major determinant of glucose homeostatic diseases, is fundamentally different from textbook models of allostery because GCK is monomeric and contains only one glucose-binding site. Prior work has demonstrated that millisecond timescale order-disorder transitions within the enzyme's small domain govern cooperativity. Here, using...

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Identifiers

PMID: 26283387
DOI: 10.1073/pnas.1506664112
PMCID: PMC4577146

Genes

GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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