The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution.

Abstract excerpt

Advances in sequencing techniques and statistical methods have made it possible not only to predict sequences of ancestral proteins but also to identify thousands of mutations in the human exome, some of which are disease associated. These developments have motivated numerous theories and raised many questions regarding the fundamental principles behind protein evolution, which have been traditionally...

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• Allosteric Regulation
• Evolution, Molecular
• Mutation
• Protein Conformation
• Proteins