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Article

Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.

Biophysical journal - 10 Mar 2020

Sternisha Shawn M, Whittington A Carl, Martinez Fiesco Juliana A, Porter Carol, McCray Malcolm M, Logan Timothy, Olivieri Cristina, Veglia Gianluigi, Steinbach Peter J, Miller Brian G

Abstract excerpt

Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dynamics underlying allostery. In contrast, faster motions have remained underexplored, hindering the development of a comprehensive model of cooperativity. Here, we map...

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Identifiers

PMID: 32023434
DOI: 10.1016/j.bpj.2019.12.036
PMCID: PMC7063420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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