Article

CAR T-cells dysfunction in the central nervous system is mediated by BBB-induced activation-induced cell death

2025-10-21

Abstract excerpt

Chimeric Antigen Receptor (CAR) T-cells can eliminate leukemia and lymphoma within the central nervous system (CNS). Following a case with CD19+ relapse in the CNS in the presence of persisting Tisagenlecleucel, we generated several models to study CAR T-cells in the CNS. In both immunocompetent and humanized leukemia-bearing mice, CNS-residing CAR T-cells were shown to have inferior ex-vivo killing capacities co...

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Literature Corpus work: 0964c00e-45bd-5bdf-975b-b7d32a04a342
DOI: 10.1101/2025.10.21.683607

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