Article

A framework for reparative CAR T engineering in the CNS

2026-02-11

Abstract excerpt

<h4>Summary</h4> Chimeric antigen receptor (CAR) T cells have shown remarkable therapeutic promise in hematological malignancies and, more recently, in autoimmunity. They also hold considerable potential for neurodegenerative diseases and CNS injury, where the therapeutic objective shifts from cell depletion to immune modulation and tissue repair. Using ischemic stroke as proof-of-concept, we engineered MOG-targe...

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Literature Corpus work: 33769920-aff0-5a8a-87b6-440cb6bdc60a
DOI: 10.64898/2026.02.09.703122

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