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Application of blood brain barrier models in pre-clinical assessment of glioblastoma- targeting CAR-T based immunotherapies

2022-03-24

Abstract excerpt

Human blood brain barrier (BBB) models derived from induced pluripotent stem cell (iPSC) have become an important tool for discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary form of gene-modified cell-based immunotherapy with potential for targeting solid tumors, such as glioblastomas. Cross...

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Literature Corpus work
056222ae-d752-5c49-89e3-5af6dac1ee9d
DOI
10.21203/rs.3.rs-1466429/v1
Open publication

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Application of blood brain barrier models in pre-clinical assessment of glioblastoma- targeting CAR-T based immunotherapiesDOI 10.21203/rs.3.rs-1466429/v1
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